At Thanksgiving, the Blake family gathers at the run-down Manhattan apartment in Chinatown of Brigid Blake and her boyfriend Richard. Brigid's parents, Erik Blake and Deirdre Blake, arrive from their home in Scranton, Pennsylvania, to have dinner with Brigid, Richard and Aimee, their other adult daughter. Brigid is a musician and Aimee is a lawyer, living in Philadelphia. Aimee has recently broken up with her girlfriend and has developed an intestinal ailment. Also present is Erik's mother Fiona "Momo", who has Alzheimer's Disease. The parents are unhappy that their daughters have left home and have abandoned their religion. The family members must deal with "aging, illness, and a changing economy".
-Sommer, Elyse. "A CurtainUp Review. The Humans ", curtainup.com, March 2, 2016